Saliva Tests Include:

  • Temporal Adrenal Profile (Cortisol Rhythm – Morning, Noon, Afternoon, Bedtime)
  • Insulin (Fasting and non-fasting)
  • 17-Hydroxyprogesterone (cortisol precursor)
  • Total salivary SIgA
  • Gluten (gliadin) antibody, sIgA (gluten sensitivity marker)

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Adrenal Stress Index: Provider Overview

The Adrenal Stress Index Panel can be helpful for patients with

  • Chronic stress and stress-related health conditions
  • Fatigue or lack of energy
  • Muscle and joint pain or weakness
  • Blood sugar dysregulation
  • Osteopenia or osteoporosis
  • Insomnia, sleep disturbances or difficulty waking
  • Poor memory or difficulty retaining information
  • Irritability or mood swings
  • Changes in skin integrity, easy bruising or excessive stretch marks
  • Frequent or chronic infections
  • Hypertension
  • Increased waist-to-hip ratio or abdominal obesity
  • Anxiety or depression

Clinical Applications of the Adrenal Stress Index (ASI)

Sleep Disorders

Sleep disorders are a very common concern among patients. A disordered circadian rhythm can be a significant contributing factor to sleep difficulties. The Adrenal Stress Index (ASI) measures cortisol levels throughout the day and evening which can help to identify these abnormal patterns. Identification of aberrant circadian rhythms can be key to proper understanding and subsequent treatment of sleep difficulties.

Glycemic Dysregulation

Chronic elevations in cortisol (often due to prolonged stress) increase blood glucose by increasing the rate of gluconeogenesis in the liver. Recurring exposure to high cortisol may potentially lead to insulin resistance. The ASI panel investigates the insulin-cortisol relationship under real-life conditions to allow targeted and effective interventions. This panel may be useful in many clinical situations including rapid weight gain or obesity, abnormal blood lipid levels, muscle wasting, early diabetes, or associated symptoms.

Allergies & Autoimmune Disorders

More than fifty years ago, it was noted that patients with environmentally-triggered allergies and autoimmune diseases dramatically improved when given cortisol for other purposes. By providing information about dynamic cortisol levels, the ASI may help to identify patients with autoimmune diseases and adrenal problems who may improve with cortisol optimization.

Other Disorders

The ASI can be a useful tool for evaluating patients with many different medical conditions. Many publications describe a hyperactive HPA axis in depressed patients. Elevated salivary cortisol can be an important screening tool for Cushing's syndrome and Cushing's disease. In Addison's disease, abnormally low levels of cortisol are produced. Other cortisol abnormalities have been correlated with attention deficit hyperactivity disorder (ADHD). Anomalous cortisol findings such as these, as well as those frequently seen in depression, can be identified using the ASI panel.